Fig. 6: A model for DNMT1 RFTS- and BAH1-regulated DNA methylation. | Nature Communications

Fig. 6: A model for DNMT1 RFTS- and BAH1-regulated DNA methylation.

From: DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation

Fig. 6

Structural elements of DNMT1, including RFTS, CXXC, autoinhibitory linker and BAH1 are colored in corn, gray, blue and pink, respectively. The BAH2 and MTase domains are colored in cyan. Histone marks (H3K9me3 and H4K20me3) cooperate with UHRF1-generated H3Ub or PAF15Ub in activation and targeting of DNMT1 for optimal DNA methylation at specific genomic loci, which in turn leads to gene repression and genomic stabilization. Note that the H3K9me3Ub and H4K20me3 marks likely regulate the activity of DNMT1 in a synergistic manner.

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