Fig. 8: Schematic outlining of how the redistribution of different actin-isoform networks and their upstream regulators could be influenced by different anaphase microtubule structures in order to drive successful cytokinesis.
From: Inhibition of polar actin assembly by astral microtubules is required for cytokinesis
In metaphase different actin-isoform networks and their upstream regulators are equally distributed around the cortex. However, these networks are differentially redistributed around the cortex upon entry into anaphase. Spindle midzone microtubules (MTs) establish the spatial cues for active β-actin assembly and furrow ingression at the equator, while astral microtubules deactivate DIAPH1 at the cell pole, depleting the polar γ-actin network that relaxes the poles, allowing blebbing and the equalization of internal hydrostatic pressure. MTs microtubules.
