Fig. 6: Mapping of small MNase DNA fragments may serve as a surrogate for transcription factor binding.
From: Multiple roles of H2A.Z in regulating promoter chromatin architecture in human cells
a Sub-nucleosomal small DNA fragments (<125 bp) and nucleosomal-sized DNA fragments (>125 bp) were extracted and aligned to C-Fos, C-Myc and STAT3 transcription factor binding sites for MCF-10A, MCF-10A+TGF-β, MCF-10CA1a and shH2A.ZMCF-10A cells. b Heatmaps, with average profiles below, were sorted on maximum occupancy of small DNA fragments (<125 bp) ±1 kb centred on the transcription factor binding site. Adjacent to each small DNA fragment heat map are H2A.Z nucleosome heatmaps sorted on the same order. H2A.Z nucleosomes flank C-FOS and STAT3 binding sites.
