Fig. 7: Loss of H2A.Z causes a dramatic increase in subnucleosomal-sized DNA fragments that map to transcription factor binding sites.
From: Multiple roles of H2A.Z in regulating promoter chromatin architecture in human cells
a Summary of the analysis. b Subnucleosomal-sized DNA fragments from all reads were extracted and aligned to all promoter regions and peak-calling was performed to detect enriched DNA sequence motifs within ±250 bp of the peak centres. c The top five DNA binding motifs that correspond to transcription factors expressed in the shH2A.Z MCF-10A cells. d The corresponding number of promoter sites at which each of these top five motifs were found in shH2A.Z MCF-10A cells. e The 93 transcription factors expressed, which recognise each of the top five DNA binding motifs in shH2A.Z MCF-10A cells. Highlighted in bold are important EMT transcription factors whose DNA recognition motif overlaps with subnucleosomal peaks that were previously occupied by H2A.Z nucleosomes.
