Fig. 8: Reduced scarring upon use of siRNA to inhibit Sox9 in wound healing. | Nature Communications

Fig. 8: Reduced scarring upon use of siRNA to inhibit Sox9 in wound healing.

From: Sox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors

Fig. 8

a Schematic diagram demonstrating experimental set up using wild-type mice. b Photo images showing wound healing over the course of 28 days (D28) post wounding between scrambled (Scr) controls and Sox9 siRNA (Sox9siRNA) treated mice. Significant increase in wound healing was observed in mice treated with (Sox9siRNA) compared to Scr (*p < 0.05; **p < 0.01 vs Scr; n = 8 biologically independent animals; mean ± SD; p value was calculated by two-way ANOVA with multiple comparison of row mean). c Significant decrease in macroscopic scar area was observed in mice treated with (Sox9siRNA) compared to Scr (**p < 0.01 vs Scr; n = 8; mean ± SD). d Quantification of skin wound sections at day 7 (D7) with endothelial markers CD31 and EndMT markers SLUG and αSMA (**p < 0.01; ***p < 0.001 vs Scr; n = 5 biologically independent animals; mean ± SD; p value was calculated by two-tailed unpaired t test).

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