Fig. 2: Upregulated PRC2⁺-CGI genes have increased promoter H3K27ac levels and accessible chromatin in tumors.

a TCGA ATAC-Seq signals for each of the three CGI promoter classes in each cancer type. Box plots indicate the median (middle line), 25th, 75th percentile (box) and 5th and 95th percentile (whiskers); the promoter number (n) of each CGI class in each cancer type is listed in Supplementary Table 2. b Aggregation plots of averaged nonmalignant and primary colon cancer cells H3K27ac ChIP-Seq signals (GSE77737) for each of the three CGI promoter classes from COAD (see Supplementary Fig. 5 for details). c Similar line plots generated using H3K27ac ChIP-Seq signal from matched nonmalignant and tumor pairs of KIRC (GSE86095, see Supplementary Fig. 5 for details). p-values between two groups in panel b, c were determined by a one-sided t-test. p < 0.0001****; p > 0.05, ns. The exact p-values are shown in Supplementary Data 4.