Fig. 5: Apoptosis defects in Cux1+/−;Flt3ITD hematopoietic stem and progenitor cells. | Nature Communications

Fig. 5: Apoptosis defects in Cux1+/−;Flt3ITD hematopoietic stem and progenitor cells.

From: Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia

Fig. 5

a, b Hematopoietic stem and progenitor cells were identified by flow cytometry and apoptosis within each compartment was determined by staining with Annexin-V (AV) and a fixable viability dye (FVD). Percentage of early- (AV+) (a) and late- (AV+FVD+) (b) apoptotic cells in LSK compartments of mice from control Con, Cux1+/−, Flt3ITD and Cux1+/−;Flt3ITD genotypes at 10-12 weeks of age (n = 6 per group). c–h Percentage of AV+ (c, e, g) and AV+FVD+ (d, f, h) apoptotic cells in MPP (c, d), LK (e, f) and GMP (g, h) compartments of mice from the indicated genotypes at 10-12 weeks of age (n = 6 per group). All plots show mean + s.e.m. Each circle represents one mouse. One-way ANOVA with Tukey’s test for multiple comparisons.

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