Fig. 2: PPARγ sustains Type-2 cytokine secretion in human ILC2s.

a Representative example of flow cytometry analysis of ILC2-derived IL-13 upon treatment (blue dot plot) or not (red dot plot) with T0070907. b Frequencies of Type-2 cytokine positive cells among ILC2s, after treatment (open blue circle) or not (open red circle) with T0070907 (n = 6; ***P = 0.0002). c Quantification of Type-2 cytokines assessed by Legendplex analysis in cell culture supernatants of ILC2s upon treatment (open blue circle) or not (open red circle) with T0070907 (n = 6; IL-13 *P = 0.048, IL-5 *P = 0.040). d Location of motifs similar to the PPARγ-RXRα binding motif (top) in the promoter region of IL-5 and IL-13 (human genome). The motifs with the lowest raw p-value found by the FIMO tool (blue) or the highest score found by the HOMER software (orange) are shown. The Integrative Genomics Viewer (IGV, v2.8.0) was used to represent the location of these motifs within the IL-5 and IL-13 promoters⁸⁴. In b–c each symbol represents one individual donor. Data are shown as mean ± SEM and were analyzed by two-way ANOVA tests. Source data are provided as a Source data file.