Fig. 3: PPARγ inhibition in ILC2s results in mitochondrial dysfunction.
From: PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions
a, c, e Representative examples of flow cytometry analysis of MitoTracker Green (a) MitoTracker Deep-red (c) and TMRM (e) in ILC2s untreated (gray histograms) and after T0070907 treatment (blue histograms) for 48 h, with their respective quantification in terms of mean fluorescence intensity (MFI), in b, d, f ILC2s untreated (open circle) and after T0070907 treatment (open aqua circle), (n = 8; Mitotracker Green *P = 0.0282, Mitotracker Deep Red **P = 0.0019, TMRM **P = 0.0036). Representative electron microscopy images (×4800 magnification; scale bars: 1 µm) (g) and quantitative plots (h) of mitochondrial volume in ILC2s untreated (open circle) and after T0070907 treatment (open aqua circle) for 48 h (n = 40 cells examined for each experimental condition over one independent experiment; *P = 0.0307). Each symbol represents one individual donor or one cell. Data are shown as mean ± SEM and were analyzed by two-tailed Wilcoxon tests. Source data are provided as a Source data file.
