Fig. 7: PPARγ expression in ILC2s influences cancer progression in a CRC murine model.

a Tumor survival of RORa^fl/sgIl7rCre positive (blue bar) or negative (red bar) mice after implantation of MC-38-IL33 murine CRC cells (ILC2 WT n = 6, ILC2 KO n = 7; *P = 0.0227). b Representative image of tumor size (left) and tumor development (right) expressed as tumor volume in ILC2 WT (open red circle), ILC2 KO (open blue circle) and ILC2 KO mice ILC2-transferred (open green circle) (n = 6; *P = 0.0473, **P = 0.0023). c Schematic representation of CRC murine model in Pparg^fl/flId2CreER^T2 mice. d Tumor development expressed as tumor volume in Pparg^fl/flId2CreER^T2 positive (open blue circle) or negative mice (open red circle) (n = 15; *P = 0.0451). e Survival of Pparg^fl/flId2CreER^T2 positive (blue bar) or negative (red bar) tumor-bearing mice (n = 5; *P = 0.0338). f Expression of Mmp9 (left) and Ncad (right) assessed by qPCR analysis in Pparg^fl/flId2CreER^T2 positive (open blue circle) or negative (open red circle) dissociated tumor tissues (n = 8; Mmp9 *P = 0.0379, Ncad *P = 0.0104). Each symbol represents one individual mouse or sample. Data are shown as mean ± SEM and were analyzed by Log-rank (Mantel–Cox) (a, e) Wilcoxon (f) or two-way (b, d) ANOVA tests. Source data are provided as a Source data file.