Fig. 6: Plasma proteins associated with the metformin treatment response.
From: Next generation plasma proteome profiling to monitor health and disease
a The longitudinal fasting plasma glucose distribution across the three visits in T2D patients with metformin treatments. The color code indicates three different drug response groups (responder, green; indeterminate, purple; non-responder, orange). b Radar plot showing median levels of top 30 proteins associated with metformin treatment response in three groups (see expression patterns of all identified proteins in Supplementary Fig. 5). c Four examples of the distribution of the plasma levels of the most significant proteins at baseline in the three drug response groups. Box plots show medians and the 25th and 75th percentiles, whiskers show the largest and smallest values (n = 40 samples), error bars represent mean ± SD. d A UMAP analysis of the expression patterns of T2D patients in the three drug response groups at baseline using the top 30 associated proteins. Source data are provided as a Source Data file.
