Table 2 The pathologic findings of kidney tissues from COVID-19 patients.
From: Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 infection
Case number | #1 | #2 | #3 | #4 | #5 | #6 |
Cause of death | ARDS | ARDS | ARDS | ARDS | ARDS | ARDS |
Coexisting disorder | ||||||
Hypertension | >10 yr | >10 yr | – | >10 yr | >5 yr | – |
Coronary disease | – | >10 yr | – | – | – | – |
Gout | – | – | – | – | Yes | – |
H&E staining | ||||||
Benign glomerulosclerosis | + | + | – | + | + | – |
Brush border exfoliation | +++ | +++ | + | + | ++ | ++++ |
Tubular necrosis | +++ | +++ | ++ | ++ | ++ | ++++ |
Interstitial infiltration | +++ | +++ | ++ | ++ | ++ | – |
Interstitial fibrosis | – | ++ | – | – | ++ | – |
Autolysis | ++ | + | + | + | + | + |
Vascular congestion | + | ++ | – | ++ | +++ | – |
IHC/IF | ||||||
Viral NP antigen | +++ | ++++ | +++ | +++ | +++ | +++ |
C5b-9 on tubules | ++ | ++++ | ++ | + | ++ | + |
DP2 | No test | ++ | +++ | ++ | No test | No test |
PDS | No test | +++ | +++ | ++ | No test | No test |
SARS-CoV-2 viral RNA | ||||||
Probe-V-nCoV2019-S | No test | +++ | No test | No test | +++ | ++ |
Probe-V-nCoV2019-S-sense | No test | +++ | No test | No test | ++ | ++ |
