Fig. 2: Integration analysis across 14 multiple myeloma patients revealing distinct cancer populations and immune microenvironments during disease progression.
From: Co-evolution of tumor and immune cells during progression of multiple myeloma
a Bar plots showing cell type fractions for each sample. Colors indicate cell type. b Single-cell variant allele fractions (VAF) for driver mutations. Each bubble is colored by the cell type with the associated VAF, and total cells supporting the variant are labeled atop each bubble. c Heatmap showing pairwise correlation of average expression for malignant cells in each sample. Genomic alterations with either FISH evidence or at least another two levels of evidence shown above. d t-SNE plots showing the integration of samples from multiple patients for a given time point. Clustering of cells from different time points are colored by patient (top) or by cell type (bottom). The remission group includes one remission sample, one pre-transplant, and one post-transplant. e Proportion of T/NK cells within the total T/NK cell cohort for each sample. The proportion of T and NK cells within each sample is shown at the bottom as a color bar. f t-SNE plot showing CD8+ T cells from all the patients where CD8+ T cells are available. Cells from the primary sample of Patients 77570 and 83942 and Relapse-2 sample of Patient 27522 are colored specifically. g Expression pattern of KMT2A and KMT2C in CD8+ T cells for each sample.
