Fig. 3: Canonical sterilizing drugs suppress rRNA synthesis more than non-sterilizing drugs in vitro. | Nature Communications

Fig. 3: Canonical sterilizing drugs suppress rRNA synthesis more than non-sterilizing drugs in vitro.

From: Mycobacterium tuberculosis precursor rRNA as a measure of treatment-shortening activity of drugs and regimens

Fig. 3

Change in RS ratio and CFU burden in time-kill experiments with a rifampin, b bedaquiline, c isoniazid, d streptomycin, and e ethambutol. Sterilizing and non-sterilizing drugs shown in orange and green, respectively. Dots represent values from three independent experiments. Lines connect mean values from each timepoint. f RNAseq results for log-phase untreated control and after 48 h of drug exposure. Integrative Genomics Viewer (IGV) images demonstrate abundant ETS1 reads in the control sample compared with near-absence of ETS1 reads after exposure to rifampin and bedaquiline. Gray shading denotes individual reads. White and blue bars indicate the ETS1 pre-rRNA and 16S rRNA regions, respectively. Source data for a–e are provided as a Source Data file.

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