Fig. 5: RS ratio correlated with the sterilizing potency of four regimens in the conventional relapsing mouse model. | Nature Communications

Fig. 5: RS ratio correlated with the sterilizing potency of four regimens in the conventional relapsing mouse model.

From: Mycobacterium tuberculosis precursor rRNA as a measure of treatment-shortening activity of drugs and regimens

Fig. 5

a Summary of treatment durations and outcomes at the end of treatment and the time of relapse assessment in the BALB/c mouse relapse model. At the end of treatment, the numbers of mice with growth of Mtb in culture and with quantifiable RS ratios are shown. The median RS ratio for each treatment is shown. At the time of relapse assessment, the numbers of mice with microbiologic relapse and with quantifiable RS ratios are shown. The median RS ratio for each treatment is shown. b RS ratio during treatment weeks 1–4 in lung homogenate from mice treated with BPaMZ (light green), BPaL (dark green), PaMZ, (light brown), or HRZE (dark brown). Circles represent values from individual mice (N = 3 per regimen at week 1 and N = 6 per regimen at weeks 2, 3, and 4). Solid lines connect median values. c RS ratio results following 4, 8, and 12 weeks of treatment with BPaL. Circles represent individual mice (N = 6 per regimen and duration) at end of treatment (EOT). Squares represent mice at the time of relapse determination (N = 15 per regimen and duration) after a 12-week drug holiday. d CFU per lung at the same timepoints in the same mice as in b with the same number of mice represented in the same color scheme.

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