Fig. 4: Cellular source of inflammatory cytokines.
From: Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection
Control DTA and Nav1.8-DTA mice were infected with HSV-OVA-TK− by flank scarification. Inflammatory cytokine production by immune cell subsets in the skin was analysed by intracellular staining and flow cytometry analysis 6 days pi. a, b Representative dot plots and quantification of the % of TNF-α+, IL-6+ and IL-1b+ monocytes (a) and neutrophils (b) in the skin of DTA and Nav1.8-DTA mice 6 days pi. c, d Absolute numbers of TNF-α+, IL-6+ and IL-1β+ monocytes (c) and neutrophils (d) in the skin of DTA and Nav1.8-DTA mice 6 days pi. The results shown are from three independent experiments (n = 7–11 mice per group). The data are presented as mean ± SEM. P values were obtained by using a Mann–Whitney test (two-tailed).
