Fig. 7: T cell and neutrophil responses are unaffected in Nav1.8-DTA mice in a model of cutaneous vaccination. | Nature Communications

Fig. 7: T cell and neutrophil responses are unaffected in Nav1.8-DTA mice in a model of cutaneous vaccination.

From: Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection

Fig. 7

a Percentages of neutrophils among CD45+ cells within the skin foot pad 5 days after the injection of an emulsion of 50% PBS and 50% complete Freund adjuvant (CFA). N = 4 per group. b–d Injection of OVA (100 μg) in CFA into the paw of the mice. b Increase (Δ) in paw thickness relative to baseline 5 days after CFA or CFA + OVA injection. N = 3–7 mice per group. c, d Percentage of OVA-specific CD8+ T cells among total CD8+ T cells (c), N = 5–10 mice per group; and absolute numbers of OVA-specific CD8+ T cells (d) in the skin-draining lymph node 7 days after the injection of CFA +/− OVA, N = 5–10 mice per group. a–d The results shown are from two independent experiments. The data shown are the mean ± SEM. P values were obtained by using a Mann–Whitney test (two-tailed).

Back to article page