Fig. 4: DNA copy number alterations and heterogeneity is associated with therapeutic resistance. | Nature Communications

Fig. 4: DNA copy number alterations and heterogeneity is associated with therapeutic resistance.

From: Longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma

Fig. 4

a Heatmap overview of the inferred copy number alterations (CNAs) in the malignant B cells across 22 chromosomes. Information on patient response status, patient and sample collection time point, were annotated in the left tracks. The yellow rectangle highlights the 17q copy number gain significantly enriched in the progression tumor B4. b A dendrogram based on the global CNV profiles showing intra-tumor cellular heterogeneity in B4 tumor cells between two subpopulations B4a to B4b. c ScRNA-seq validation of 17q gain in cells from B4-derived PDX tumors. d Cross-platform validation of the 17q gain in additional patient cohorts and resistant MCL cell lines using deep whole-exome sequencing (WES). The Log2Ratio plots of 4 representative samples are shown. e Expression heatmap showing genes upregulated in the progression tumor B4 and located at 17q.

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