Fig. 4: The correlation between T cell clonality and T cell subtypes. | Nature Communications

Fig. 4: The correlation between T cell clonality and T cell subtypes.

From: Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features

Fig. 4

a Th1 (average value of marker genes IFNG, IL12A, IL12B) measured by gene expression from nCounter PanCancer Immune Profiling Panel. Fractions of CD8+ T cells (b) and CD4+ T cells (e) inferred from gene expression profiling using TIMER. c CD8+CTLs (CD3+CD8+granzyme B+), d ThCTLs (CD3+CD8–Granzyme B+), f CD3+CD8– T cells, and g Tregs (CD3+CD8–FoxP3+) measured by mIF. The correlation coefficient (rho) was assessed by two-tailed Spearman’s rank correlation test. Data from 35 patients was used including NL (normal lung tissue), AAH (atypical adenomatous hyperplasia), AIS (adenocarcinoma in situ), MIA (minimally invasive adenocarcinoma), and ADC (invasive adenocarcinoma). (Source data is provided as a source data file).

Back to article page