Fig. 6: Association of preinfection baseline gene expression with clinical features of rDEN2Δ30 infection. | Nature Communications

Fig. 6: Association of preinfection baseline gene expression with clinical features of rDEN2Δ30 infection.

From: Immunotranscriptomic profiling the acute and clearance phases of a human challenge dengue virus serotype 2 infection model

Fig. 6

a Genome-wide absolute baseline gene expression level counts (rows) were queried against ten clinical laboratory parameters (columns) associated with rDEN2Δ30 infection including peak viremia, neutralizing antibodies and changes in blood cell counts across the 11 subjects. Only genes (rows) that had an absolute correlation >0.9 for at least one of the columns are pictured. Darker colors represent a stronger correlation; while blue and red represent positive and negative correlation, respectively. Unsupervised clustering identified 49 genes and three major groups (I–III) distinguishing amongst the parameters. b–d Pathway analysis and GO terms associated with Group 1 (b), Group II (c), and Group III (d) gene associations and unadjusted P values with FDR < 0.1 are shown. Source data are provided as a Source Data file.

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