Fig. 2: Principal components and mortality risk.
From: Taxonomic signatures of cause-specific mortality risk in human gut microbiome
Association between mortality risk and the first three principal components of beta diversity (PC). Black line indicates the estimated hazard ratio compared to median PC value and blue area the 95% confidence interval (CI). Unit variance increase in the PCs were related to hazard ratios of 0.92 (95% CI, 0.85–0.99; FDR-adjusted P = 0.065; two-tailed Wald test), 0.95 (95% CI, 0.87–1.02; FDR-adjusted P = 0.17; two-tailed Wald test) and 1.14 (95% CI, 1.07–1.23; FDR-adjusted P = 0.001; two-tailed Wald test) for PC1–PC3, respectively. Analyses are adjusted for age, body mass index, sex, smoking, diabetes, use of antineoplastic and immunomodulating agents, systolic blood pressure and self-reported antihypertensive medication. The dashed line represents a hazard ratio of 1 set at median PC value. HR hazard ratio.
