Fig. 4: Taxonomic subnetwork associated with increased mortality risk.
From: Taxonomic signatures of cause-specific mortality risk in human gut microbiome
a Abundance variation across the study population for the subnetwork that exhibits the strongest mortality associations (CLR-transformed abundances centred at zero and scaled to unit variance). The samples are ordered by the total relative abundance of the subnetwork. b The observed subnetwork structure and mortality risk. The total subnetwork abundance was associated with elevated mortality with a hazard ratio of 1.155 (95% confidence interval [CI], 1.08–1.24; P = 0.0002, Wald two-tailed test statistic for Cox regression, 4.07) The respective hazard ratios were 1.17 (95% CI, 1.07–1.27; P = 0.001, Wald statistic 3.66) in the Eastern and 1.14 (95% CI, 1.001–1.31; P = 0.15, Wald statistic 2.02) in the Western Finnish populations. The analyses are conducted after excluding rare taxa and adjusted for age, body mass index, sex, smoking, diabetes, use of antineoplastic and immunomodulating agents, systolic blood pressure and self-reported antihypertensive medication; P values are FDR-adjusted.
