Fig. 2: Late genes are more polymorphic for nonsynonymous mutations.
From: Molecular evolution and the decline of purifying selection with age
Genes that are more highly expressed late in life are significantly more polymorphic for nonsynonymous mutations than are genes expressed early in all four species. Nonsynonymous polymorphism is measured here as the fraction of sites in a gene that segregate for nonsynonymous alleles (pN) relative to the fraction segregating for synonymous alleles (pS). Significance was determined by Spearman rank correlations, and p-values in bold are significant at p < 0.05 (two-sided tests, not corrected for multiple tests). The lines are least squares regressions, and the gray regions show the approximate 95% confidence intervals for the regressions. See also Supplementary Fig. 2 and Supplementary Table 1.
