Fig. 5: Selection on late genes is weaker.
From: Molecular evolution and the decline of purifying selection with age
The relative strength of selection is significantly weaker in late-expressed genes than early-expressed genes in three of the four species. The estimates of Ne s are based on a highly simplified model that assumes beneficial mutations have fitness effect s and deleterious mutations fitness –s. Significance was determined by Spearman rank correlations, and p-values in bold are significant at p < 0.05 (two-sided tests, not corrected for multiple tests). The lines are least squares regressions, and the gray regions show the approximate 95% confidence intervals for the regressions. See also Supplementary Fig. 5 and Supplementary Table 1.
