Fig. 8: h2a.w-2 and h1 h2a.w show opposite changes in accessibility and non-CG methylation. | Nature Communications

Fig. 8: h2a.w-2 and h1 h2a.w show opposite changes in accessibility and non-CG methylation.

From: The histone variant H2A.W and linker histone H1 co-regulate heterochromatin accessibility and DNA methylation

Fig. 8

The genome was divided into consecutive, non-overlapping 4-kb bins, which are stacked according to their genomic position from the top of chromosome 1 to the bottom of chromosome 5. Pericentromeric regions are indicated (peri.1 to peri.5). H2A.W enrichment in the WT (log2 ChIP/H3) is shown as a heat map on the left. Other heat maps show changes in H1 levels (h2a.w-2/WT; log2 ChIP/H3), changes in chromatin accessibility (log2 mutant/WT; ATAC-seq read depth), and changes in CHG and CHH DNA methylation (mutant minus WT) in h2a.w-2 versus WT and in h1 h2a.w versus WT.

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