Fig. 7: Predicted impact of BAT binding on the Rad50–Mre11 complex and model for MRX inhibition by Rif2 at telomeres. | Nature Communications

Fig. 7: Predicted impact of BAT binding on the Rad50–Mre11 complex and model for MRX inhibition by Rif2 at telomeres.

From: Mechanism of MRX inhibition by Rif2 at telomeres

Fig. 7

A Models of S. cerevisiae Rad50–Mre11 complex in the ATP-bound resting state (left) and in the DNA-bound active state (right). Residues K6, K81 and I93 highlighted in red. Bottom panel: envelope of the BAT core peptide (Rif2 residues 4-14, in brown) belonging to the HADDOCK cluster 1 shown after superimposition of the Rad50 structures of the clusters on that of the DNA-bound Rad50–Mre11 complex model. B Model for telomere protection by Rif2 at telomeres (Rad50 orange/yellow, Mre11 teal/light blue, Rap1 grey, Rif2 pink, BAT and BAT interacting region on Rad50 red). For simplicity, Xrs2 and other factors present at broken ends and at telomeres are not represented.

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