Table 2 Benchmark of Typhi Pathogenwatch AMR predictions.
Antibiotic | Total | TN | TP | FN | FP | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | PPV (95% CI) | VME rate | ME rate | Concordance (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
AMP | 875 | 461 | 402 | 4 | 8 | 0.99 (0.97–1.00) | 0.98 (0.97–0.99) | 0.98 (0.96–0.99) | 0.99 (0.98–1) | 0.01 | 0.02 | 98.63 |
CEP | 348 | 256 | 90 | 2 | 0 | 0.98 (0.92–1.00) | 1.00 (0.99–1.00) | 1.00 (0.96–1.00) | 0.99 (0.97–1.00) | 0.02 | 0 | 99.43 |
CHL | 913 | 518 | 375 | 6 | 14 | 0.98 (0.97–0.99) | 0.97 (0.96–0.99) | 0.96 (0.94–0.98) | 0.99 (0.98–1.00) | 0.02 | 0.03 | 97.81 |
CIP | 1282 | 111 | 1065 | 49 | 57 | 0.96 (0.94–0.97) | 0.66 (0.58–0.73) | 0.95 (0.93–0.96) | 0.69 (0.62–0.76) | 0.04 | 0.32 | 91.73 |
SXT | 912 | 513 | 367 | 7 | 25 | 0.98 (0.96–0.99) | 0.95 (0.93–0.97) | 0.94 (0.91–0.96) | 0.99 (0.97– 0.99) | 0.02 | 0.05 | 96.49 |
TCY | 44 | 40 | 4 | 0 | 0 | 1.00 (0.40–1.00) | 1.00 (0.91–1.00) | 1.00 (0.40–1.00) | 1.00 (0.91–1.00) | 0 | 0 | 100 |
AZM | 156 | 144 | 12 | 0 | 0 | 1.00 (0.74–1.00) | 1.00 (0.97–1.00) | 1.00 (0.74–1.00) | 1.00 (0.97–1.00) | 0 | 0 | 100 |
CST | 41 | 41 | 0 | 0 | 0 | – | 1.00 (0.91–1.00) | – | 1.00 (0.91–1.00) | – | 0 | 100 |
MEM | 132 | 132 | 0 | 0 | 0 | – | 1.00 (0.97– 1.00) | – | 1.00 (0.97– 1.00) | – | 0 | 100 |
