Fig. 4: Synthesis of gem-difluoroalkenes by diazaphospholene-catalyzed HDF of trifluoromethylalkenes. | Nature Communications

Fig. 4: Synthesis of gem-difluoroalkenes by diazaphospholene-catalyzed HDF of trifluoromethylalkenes.

From: Chemoselective catalytic hydrodefluorination of trifluoromethylalkenes towards mono-/gem-di-fluoroalkenes under metal-free conditions

Fig. 4

General reaction conditions: 2 (0.3 mmol), 1 (5 mol%), PhSiH3 (0.33 equiv.) and CH3CN (1 mL) were mixed in a tube under Ar. Isolated yields were given. [a] Determined by 19F NMR spectroscopy. [b] Isolated yields for gram-scale synthesis: 2j or 2 l (5.0 mmol), 1 (5 mol%), PhSiH3 (0.33 equiv.), CH3CN (5 mL), 50 oC, 3 h.

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