Fig. 6: An example of a putative causal eQTL prioritized by EMS. | Nature Communications

Fig. 6: An example of a putative causal eQTL prioritized by EMS.

From: Leveraging supervised learning for functionally informed fine-mapping of cis-eQTLs identifies an additional 20,913 putative causal eQTLs

Fig. 6

rs35873233, an upstream variant of CITED4, was prioritized by functionally informed fine-mapping using EMS as a prior. From top to the bottom: PIP with uniform prior (PIPunif), EMS, PIP with EMS as a prior (PIPEMS); Basenji score for CAGE46 activity in acute myeloid leukemia (AML), H3K27me3 narrow peak in K562 cell line (red if the variant is on the peak, blue otherwise), sequence context60 of the alternative allele aligned with the binding motif61 of SPI1, and PIP for neutrophil count in UKBB (https://www.finucanelab.org/data, ref. 34) with uniform prior.

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