Fig. 1: Cryo-EM structure of a 16-mer AENTH complex. | Nature Communications

Fig. 1: Cryo-EM structure of a 16-mer AENTH complex.

From: Structure of the endocytic adaptor complex reveals the basis for efficient membrane anchoring during clathrin-mediated endocytosis

Fig. 1

a Cryo-EM reconstruction obtained for the 16-mer complex formed by 8 ANTH and 8 ENTH units (A8E8). The density corresponding to ANTH and ENTH is colored correspondingly in cyan and gray. b Model of the A8E8 complex built based on the EM density shown in cartoon representation. One tetramer is colored with the ANTH domains in cyan and ENTH domains in gray (see Supplementary Fig. 4 for symmetry axes). c The building unit is the AENTH tetramer (A2E2) shown in cartoon and surface representation, with the ENTH domains in gray and the ANTH domains in cyan. The PIP2 polar heads bound to the tetramer are shown in stick representation (gold). A schematic of the tetramer is shown next to the structure.

Back to article page