Fig. 6: Ca-DelMut immunization protection against WT virus challenge in hamsters. | Nature Communications

Fig. 6: Ca-DelMut immunization protection against WT virus challenge in hamsters.

From: Characterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein

Fig. 6

Hamsters were inoculated with 1.25 × 105 pfu Ca-DelMut (n = 12) or mock immunized (n = 12). At day 28 after immunization, hamsters were challenged with 1 × 103 pfu of either HK-13 (n = 6) or HK-95 (n = 6) virus. A Body weight and disease symptoms were monitored for 5 days. Error bars represent mean ± SD (n = 3). Statistical comparisons between means were performed by two-way ANOVA with Bonferroni post-test: ****p < 0.0001, ***p < 0.001, **p < 0.01. B At days 2 and 5 post-infection, lungs and nasal turbinate tissues were collected for virus titration and histopathological study. Error bars represent mean ± SD (n = 3). Statistical comparisons between means were performed by Student’s t-test (2-tailed): *p < 0.05, NS: not significant.

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