Fig. 4: Archetype shifts and experimental validation of metabolic capacity.
From: Evolution of core archetypal phenotypes in progressive high grade serous ovarian cancer
a Stacked bar plots showing the proportion of specialists at biological tasks and non-specialists in the early/late patient cohorts. b Boxplots comparing the proportions of each task specialist between the early (n = 8) and late (n = 6) cohort samples. P value indicates significance in difference of means (two-tailed Student’s t test). The lower and upper hinges in the boxplot indicate 25th and 75th percentiles and middle indicates 50th percentile (median), while the whiskers extended over 1.5× interquartile range. c, d Dot plots displaying glycolysis, oxidative phosphorylation (OXPHOS), and total ATP production in cell lines developed using the malignant cells isolated from patients 4 and 8 (c) and patients 16, 17, 21, and 23 (d). Vertical black bars indicate standard error of the mean (SEM) across three independent biological replicates. The horizontal bars with an asterisk indicate a significant difference (FDR < 0.05) in mean ATP production rates. The comparisons were performed for all time points in (c), and the joint means between early and late cohort patients in (d). Source data for ATP production assay are provided as Source Data file.
