Fig. 1: Schematic illustration of SPNpro-mediated IDO degradation for cancer photo-immunometabolic therapy.
From: Semiconducting polymer nano-PROTACs for activatable photo-immunometabolic cancer therapy
a Structure and cathepsin B (CatB)-specific activation mechanism of SPNpro. b SPNpro-mediated activatable photo-immunometabolic therapy with two processes: (i) a series of cancer immune responses including immunogenic cell death (ICD), tumor-associated antigen release, DC maturation, and effector T (Teff) cell activation upon NIR photoirradiation; (ii) SPNpro-mediated immunometabolic intervention processes including CatB-specific activation of IPP, IDO and VHL targeting, proteasome recruitment, IDO degradation, Trp upregulation and Kyn depletion, and Teff cell activation.
