Fig. 2: Zinc chelators contract selected rat and human isolated arteries.
From: Zinc drives vasorelaxation by acting in sensory nerves, endothelium and smooth muscle
a Chemical structures of the cell-permeable zinc chelators used: TPA (i) and TPEN (ii). b–d Selective contractile effects of the zinc-selective chelators, TPA (b) and TPEN (c) on resting (basal) tone in vessels from rats and humans (d). e Zinc added after contraction of middle cerebral arteries with TPEN (100 µM) caused reversal of the effect. f Zinc levels per wet weight in rat arteries. Whiskers are min to max values and boxes are 25–75th percentile, where the line inside the box is the median and the + sign is the mean. Responses in b–e are %KPSS. Error bars are SEM (those not shown are contained within the symbol). n, number of arteries isolated from individual rats/humans. *Statistically significant, mixed-effects 1-way ANOVA [F(1.55, 6.2) = 62.81, p = 0.0001] with Dunnett’s post-test compared to TPEN tone in e and Kruskal–Wallis test [H(3) = 20.97, p = 0.0001] with Dunn’s post-test in (f).
