Fig. 3: Spectroscopic fingerprint SRS imaging of mouse whole brain. | Nature Communications

Fig. 3: Spectroscopic fingerprint SRS imaging of mouse whole brain.

From: Microsecond fingerprint stimulated Raman spectroscopic imaging by ultrafast tuning and spatial-spectral learning

Fig. 3

a–c Fingerprint spectroscopic SRS imaging of mouse brain by single raw acquisition, network recovery, and 100 averaging ground truth (GT). d Quantitative analysis of network recovery quality for mouse brain. Box plots (n = 15) show the NRMSE and SSIM for raw vs. GT and network vs. GT. The boxes show interquartile range (IQR), the red line indicates medians, the black lines represent whiskers which extend to 1.5 times of the IQR and the red data points are the outliers exceeding the whiskers. NRMSE normalized root mean square error, SSIM structural similarity index. e–g Protein, fatty acid, and cholesterol maps of a mouse whole-brain slice after SS-ResNet recovery. h Mouse whole-brain composite chemical maps consisting of protein (blue), fatty acid (red), and cholesterol (green). Different colors indicate different percentage concentrations from the three channels. i Zoom-in images of different mouse brain areas. Circled regions in the DG area include rare cells with high cholesterol content. LH lateral hypothalamus, BM basal amygdaloid, VP ventral posterior nucleus, CPu caudate putamen, DG dentate gyrus, HC hippocampus.

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