Fig. 1: Sex-dependent physiological differences.

Schematic representation of male/female differences in (A) DNA methylation, (B) sex chromosomes, (C) metabolome, lipidome, and proteome, (D) immune cells, (E) hormone production (during E1) pregnancy, E2 menopause, E3 puberty, (F) plasma composition, (G) mosaicism, and (H) X-chromosome inactivation.