Fig. 4: Density at the Taxol-binding site of β-tubulin. | Nature Communications

Fig. 4: Density at the Taxol-binding site of β-tubulin.

From: Cryo-EM structure of cortical microtubules from human parasite Toxoplasma gondii identifies their microtubule inner proteins

Fig. 4

a Close-up view of the cryo-EM density of one α,β-tubulin dimer at protofilament P4. Unexplained density (cyan, pointed by a red arrow) can be observed at the Taxol-binding site of β-tubulin (gray), but its size and shape are inconsistent with Taxol (c, d). b Same view as a, but showing the atomic models together with the unexplained density. Atomic models of TrxL1 and SPM1 are hidden for clarity. c Close-up view of the cryo-EM density of one α,β-tubulin dimer of taxol-stabilized bovine MT (EMD-21924)66. d Atomic model of the cryo-EM density shown in (c) (PDB 6WVR)66. e Atomic model of zampanolide-stabilized porcine MT (PDB 5SYG)67. f Atomic model of epothilone-stabilized yeast MT (PDB 5W3H)68.

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