Fig. 8: Proposed role of Meis in limb initiation and AP prepatterning.
From: Control of mouse limb initiation and antero-posterior patterning by Meis transcription factors
During limb initiation (a), Meis is required in parallel to Tbx factors for activation of the Wnt target Lef1 and Fgf10, both essential for limb-bud formation and progression. This function is similar in FLs and HLs. During AP patterning in the FL (b), Meis is required directly or indirectly for the activation of various prepatterning genes, like Hoxd9, Hoxd13, and Hand2, all involved in Shh activation.
