Table 2 Common mutations (allele frequency %) in putative drug-resistance genes.

From: Distinctive genetic structure and selection patterns in Plasmodium vivax from South Asia and East Africa

Gene name	Position	Amino acid change	South Asia (n = 92)	East Africa (n = 50)	South America (n = 148)	SEA (n = 186)	South SEA (n = 84)
pvdhfr	1077510	N50I	7.1
pvdhfr	1077530/2	F57I				56.2
pvdhfr	1077530/2	F57L				4.3	76.5
pvdhfr	1077534	K58R			8.8
pvdhfr	1077535	S58R	34.5	88.0	67.9	100	62.2
pvdhfr	1077543	T61M				64.9	36.5
pvdhfr	1077711	N117T			0.7	64.1	72.6
pvdhfr	1077711	N117S	62.2	6.3	20.3		9.5
pvdhfr	1078090	D243E	3.6
pvdhfr	1078180	N273K	10.7
pvdhps	1270256	M601I	6.6
pvdhps	1270401	A553G	11.0		0.6	67.6	54.1
pvdhps	1270524	K512M				3.8
pvdhps	1270683	D459A	3.3
pvdhps	1270793	C422W					15.3
pvdhps	1270911	G383A	86.7	68.0	47.2	3.8	32.1
pvdhps	1270914	S382C			10.6
pvdhps	1270915	S382A				21.1
pvdhps	1270966	F365L	4.4
pvdhps	1271444	M205I*		72.0	59.2	100	8.2
pvdhps	1271634	E142G*		64.0
pvdhps	1271664	E132G*					38.8
pvmdr1	478789	L1449I	7.8
pvmdr1	478955	K1393N	11.2	2.0		10.8	1.2
pvmdr1	479329	T1269S	10.1
pvmdr1	479908	L1076F	2.2		88.1	33.5	1.2
pvmdr1	480207	F976Y	97.8	46.0	89.9	68.7	11.9
pvmdr1	480412	L908M			13.5
pvmdr1	480552	A861E	4.4			3.8
pvmdr1	480601	L845F	14.3			8.7	2.4
pvmdr1	480846	A763V				3.8
pvmdr1	481042	S698G	59.3	38.0	100	0.5
pvmdr1	481595	S513R	35.6	72.0	0.6	23.2
pvmdr1	481636	D500N			17.3
pvmdr1	481908	T409M	11.1
pvmdr1	482473	V221L			18.9
pvmrp1	153954	N1657S					30.1
pvmrp1	154065	I1620T					4.7
pvmrp1	154107	A1606D			7.5
pvmrp1	154108	A1606T			7.6
pvmrp1	154168	H1586Y	9.3		28.9	3.8
pvmrp1	154216	D1570Y					3.5
pvmrp1	154294	V1544I			8.5
pvmrp1	154350	T1525I			6.3
pvmrp1	154492	I1478V	20.3	23.5	15.4
pvmrp1	154668	G1419A	23.4	16.7	33.8
pvmrp1	154747	D1393Y	18.3	4.9		0.5
pvmrp1	154831	L1365F					3.5
pvmrp1	154843	L1361F	3.0			0.5
pvmrp1	155080	L1282I			9.6
pvmrp1	155305	L1207I				85.4
pvmrp1	155871	C1018Y			6.1
pvmrp1	156208	E906Q	42.6	48.6	24.8	4.3	9.4
pvmrp1	157300	K542E	14.1	2.5	1.4
pvmrp1	158148	R259T*	39.3	50.0	13.3	0.5
pvmrp1	158223	T234M				84.0	1.2
pvpm4	1802108	I165V	7.7	24.5	66.3	56.2	22.6

Allele frequency bolded if >50%; South Asia (Afghanistan, Bangladesh, India, Sri Lanka, Pakistan); East Africa (Eritrea, Ethiopia, Madagascar), South America (Brazil, Colombia, Guyana, Peru, Mexico); SEA (Cambodia, China, Laos, Myanmar, Thailand, Vietnam); Southern SEA (Malaysia, Papua New Guinea, Indonesia, The Philippines); * in the HPPK-coding part of the bifunctional gene.

Back to article page

Table 2 Common mutations (allele frequency %) in putative drug-resistance genes.

Search

Quick links