Fig. 4: Manganese-catalyzed fluorescent labeling of complex peptides via late-stage C–H stitching.
From: Chemodivergent manganese-catalyzed C–H activation: modular synthesis of fluorogenic probes
Synthesis of peptides 47–53 featuring a bent linker between the BODIPY fluorophore and the tryptophan via C–H stitching, late-stage diversification of natural product derivatives featuring the 2,5-diketopiperazine core (54–57) and synthesis of fluorescent cyclic peptides via C–H alkenylation.
