Fig. 6: Mapping of 3 miRNAs to classify prostate cancer stages. | Nature Communications

Fig. 6: Mapping of 3 miRNAs to classify prostate cancer stages.

From: Single-molecule amplification-free multiplexed detection of circulating microRNA cancer biomarkers from serum

Fig. 6

a Heat map of two up-regulated (miR-141-3p & miR-375-3p) and one down-regulated (let-7b) miRNAs in prostate cancer patients with advanced localised (n = 3), metastatic (n = 3) disease and patients in remission (n = 7). NC, negative control. b–d Relative expression levels of b miR-141-3p, c miR-375-3p and d let-7b in negative controls, remission patients, advanced localised and metastatic disease patients. Values described were obtained from 3 technical replicates. Data are presented as mean ± s.d. Statistical significance was tested using two-tailed Student’s t-test; *P < 0.05. For localised disease, P = 0.001, 0.0117 and 0.0246 for miR-141-3p, miR-375-3p and let-7b, respectively. For metastatic, P = 0.0222, 0.0497 and 0.0238, for miR-141-3p, miR-375-3p and let-7b, respectively.

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