Table 2 Predicted amino acids for the eight A-domains appearing on cyclic surugamides A–D assembly line SurugamideAL.

From: Integrating genomics and metabolomics for scalable non-ribosomal peptide discovery

\(A\)1

\(A\)2

\(A\)3

\(A\)4

\(A\)5

\(A\)6

\(A\)7

\(A\)8

Val (100)

Phe (100)

Tyr (100)

Val (100)

Ala (100)

Val (100)

Val (100)

Met (100)

Ile (80)

Tyr (90)

Phe (100)

Ile (100)

Ser (87)

Ile (100)

Ile (100)

Apa (100)

Abu (70)

Bht (90)

Leu (100)

Abu (70)

Pro (75)

Abu (70)

Abu (70)

Glu (86)

    

Val (75)

  

Arg (86)

    

Cys (75)

  

Gln (86)

    

Phe (75)

  

Lys (86)

    

Gly (75)

  

Asp (86)

       

Val (86)

       

Orn (86)

  1. Ai represents the set of amino acids predicted for the ith A-domain in \({\rm{SurugamideAL}}\). For each Ai at least three amino acids with the highest normalized specificity scores (listed in parentheses) are presented. Amino acids appearing in surugamide A (IFLIAIIK) are shown in bold. NRPminer considers all amino acids with the same normalized specificity score, as illustrated in the case of the fifth and the eighth A-domains.