Fig. 1: Overall structure of D1R in complex with Gs and non-catechol agonist Compound 1.
From: Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist
a The structure of D1R and Gs are shown in cartoon, and ligand Compound 1 is shown in spheres. D1R: green; Compound 1: lime; Gαs: blue; Gβ: orange; Gγː purple; Nb35: light pink. b Superimposition of D1R-Gs structure with β2AR-Gs structure by receptor (gray for β2AR, cyan for Gαs, light orange for Gβ, violet for Gγ; PDB ID: 3SN6) shows a longer TM5-ICL3 helix in D1R, which interacts with the α4 helix and α4-αg loop of Gαs. c Differences in the relative orientation of the Gs trimer and receptor for D1R-Gs and β2AR-Gs structures following superimposition of the receptors.
