Fig. 2: The binding of non-catechol agonist Compound 1 to D1R.
From: Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist
a The chemical structure of Compound 1. b Binding pocket of Compound 1. Residues within the interaction distance of the ligand are shown in stick. Hydrogen bonds are depicted with dashed lines. c ECL2 of D1R adopts a unique bulged conformation to accommodate Compound 1 (shown in stick). D1R structure is aligned with multiple aminergic receptor structures. All other bound ligands are shown in lines. D1R: green, Compound 1: lime; β2AR, gray (PDB ID: 4LDO); D2R: orange (PDB ID: 6VMS); 5-HT2C, magenta (PDB ID: 6BQG); 5-HT1B, yellow (PDB ID: 4IAR); β1AR, purple (PDB ID: 2Y03); D4R, cyan (PDB ID: 5WIV); D3R, blue (PDB ID: 3PBL); 5-HT2B, dark green (PDB ID: 4IB4). d Surface representation of Compound 1 binding pocket. Compound 1 is shown in spheres, while the side chain of Leu190 on ECL2 of D1R is shown in stick.
