Fig. 1: Major steps of iCAL. | Nature Communications

Fig. 1: Major steps of iCAL.

From: Model-based analysis uncovers mutations altering autophagy selectivity in human cancer

Fig. 1

i Design a sequence-based predictor, pLIRm, and develop a model-based approach, pLAM; ii computational prioritization of potential LAMs that significantly influence cLIR motifs, and then pan-cancer analysis and experimental validation of predicted LAM-containing LIRCPs; iii combine transcriptomics, metabolomics with additional experimental assays to study the role and mechanism of STBD1 in tumor proliferation; Co-IP co-immunoprecipitation.

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