Fig. 1: Administration of VEGFC mRNA-LNPs induces VEGFC secretion in vivo. | Nature Communications

Fig. 1: Administration of VEGFC mRNA-LNPs induces VEGFC secretion in vivo.

From: Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema

Fig. 1

a 1 µg of Poly(C) or VEGFC mRNA-LNPs were injected into contralateral ears of mice intradermally. Interstitial fluid samples were harvested 1, 5, 10, 15, and 20 days post injection and VEGFC protein expression levels were determined by ELISA. Quantitative data for secreted amount of VEGFC are represented as mean and SEM from Poly(C) or VEGFC mRNA-LNP injected ears of 3–4 mice at each time point (two-tailed, paired T-test, P = 0.0023 after 1 day for 3 mice, P = 0.0063 after 5 days for 4 mice, P = 0.0017 after 10 days for 4 mice, P = 0.0332 after 15 days for 4 mice, and P = 0.7025 after 20 days for 4 mice). Asterisks indicate P < 0.05 compared with control.

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