Fig. 3: Disruption of the SUN1–SPDYA interaction impairs extensive alignment of chromosome ends.
From: The SUN1-SPDYA interaction plays an essential role in meiosis prophase I
a Heatmaps showing normalized Hi-C interactions (observed/expected) for the entire Chr2 (top, 50-kb bin) or a 4 Mb Chr2 region (bottom, 10-kb bin) in WT zygotene and W151R pachytene-like spermatocytes. WT zygotene data is from Patel et al.25. b Heatmaps showing normalized Hi-C interactions between Chr1 and Chr2 (50-kb bin) in WT zygotene and W151R pachytene-like spermatocytes. In WT spermatocytes, the chromosome ends preferentially interact with each other in trans. In W151R mutant, the clustering of chromosome ends is greatly diminished. Cen centromeric regions. c Boxplot shows changes in normalized interchromosomal interactions among the 10 Mb regions at the centromeric (Cen) or noncentromeric (Tel) ends of autosomes in W151R mutant (N = 171, 171, 171, 171, 342, 342 for each column, respectively). Boxes, middle 50% of interchromosomal interaction scores. Center bars, lower bounds of boxes and upper bounds of boxes indicate median scores, the first quartile of scores (Q_1) and the third quartile (Q_3) of scores, respectively. Upper and lower whiskers correspond to min(max(x), Q_3 + 1.5 * IQR) and max(min(x), Q_1 − 1.5 * IQR). IQR interquartile range.
