Fig. 3: Detecting biomolecules with mid-IR spectroscopy.
From: Nanophotonic biosensors harnessing van der Waals materials
a Reflection-mode in situ SEIRA detection of multiple biological analytes. b Time-resolved and molecule-specific in situ SEIRA monitoring of the lipid membrane formation and disruption dynamics. Lipid vesicles rupture on SiO2-coated gold antennas and form a supported lipid bilayer membrane. Subsequent injection of cytolytic peptide, melittin, forms pores and disrupts the membrane. a, b Adapted from ref. 47 with permission. c Calculated electric field enhancement for a gold nanotenna in a buffer. Distance dependence of SEIRA signal comparing computer simulations (dotted) and measured absorbance data (full dots). Reprinted from ref. 48 with permission. d Graphene liquid cell for detection of biomolecules trapped in a thin layer of water. Reprinted from ref. 50 with permission.
