Fig. 2: Proposed catalytic cycle for the copper-catalyzed carbo-difluoromethylation of alkenes. | Nature Communications

Fig. 2: Proposed catalytic cycle for the copper-catalyzed carbo-difluoromethylation of alkenes.

From: Copper-catalyzed carbo-difluoromethylation of alkenes via radical relay

Fig. 2

The proposed mechanism involves the single electron transfer (SET) from a [Cu-CF2H] species to an electrophile to form a carbon-centered radical, which reacts with an alkene to afford a relayed radical. The relayed radical reacts with a [CuII-CF2H] species to form the difluoromethylated product.

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