Fig. 4: Copper-catalyzed difluoromethyl-alkylation of alkenes.
From: Copper-catalyzed carbo-difluoromethylation of alkenes via radical relay
Reactions were run with 0.25 mmol of RAEs, 0.75 mmol of alkenes (3.0 equiv.), 0.2 mmol of (terpy)Zn(CF2H)2 (0.8 equiv.), and CuCl (30 mol%) in 1 mL of DMSO at r.t., isolated yields based on RAEs. aReaction performed under modified conditions (Supplementary Method 5). terpy, 2,2ʹ;6ʹ,2ʺ-terpyridine; DMSO, dimethyl sulfoxide.
